Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
| PAG Title | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
| PAG ID | WIG000535 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure, characterized by the substructure Man (a14) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane, (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis gene result in a genetic disorder, paroxysmal nocturnal hemoglobinuria. |
| Species | Homo sapiens |
| nCoCo Score | 1,484 |
| Base PAG ID | WIG000535 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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